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Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with infrequent and rare variants using whole-exome...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:JAMA Neurol
Main Authors: Ma, Yiyi, Jun, Gyungah R., Zhang, Xiaoling, Chung, Jaeyoon, Naj, Adam C., Chen, Yuning, Bellenguez, Celine, Hamilton-Nelson, Kara, Martin, Eden R., Kunkle, Brian W., Bis, Joshua C., Debette, Stéphanie, DeStefano, Anita L., Fornage, Myriam, Nicolas, Gaël, van Duijn, Cornelia, Bennett, David A., De Jager, Philip L., Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A., Seshadri, Sudha, Lambert, Jean-Charles, Schellenberg, Gerard D., Lunetta, Kathryn L., Farrer, Lindsay A.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Medical Association 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563544/
https://ncbi.nlm.nih.gov/pubmed/31180460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1456
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