Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype

IMPORTANCE: Previous genome-wide association studies of common variants identified associations for Alzheimer disease (AD) loci evident only among individuals with particular APOE alleles. OBJECTIVE: To identify APOE genotype-dependent associations with infrequent and rare variants using whole-exome...

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發表在:JAMA Neurol
Main Authors: Ma, Yiyi, Jun, Gyungah R., Zhang, Xiaoling, Chung, Jaeyoon, Naj, Adam C., Chen, Yuning, Bellenguez, Celine, Hamilton-Nelson, Kara, Martin, Eden R., Kunkle, Brian W., Bis, Joshua C., Debette, Stéphanie, DeStefano, Anita L., Fornage, Myriam, Nicolas, Gaël, van Duijn, Cornelia, Bennett, David A., De Jager, Philip L., Mayeux, Richard, Haines, Jonathan L, Pericak-Vance, Margaret A., Seshadri, Sudha, Lambert, Jean-Charles, Schellenberg, Gerard D., Lunetta, Kathryn L., Farrer, Lindsay A.
格式: Artigo
語言:Inglês
出版: American Medical Association 2019
主題:
Original Investigation
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6563544/
https://ncbi.nlm.nih.gov/pubmed/31180460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2019.1456
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