Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities

C-terminal binding proteins (CtBP1/2) are oncogenic transcriptional coregulators and dehydrogenases often overexpressed in multiple solid tumors, including breast, colon, and ovarian cancer, and associated with poor survival. CtBPs act by repressing expression of genes responsible for apoptosis (e.g...

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Pubblicato in:Mol Pharmacol
Autori principali: Dcona, M. Michael, Damle, Priyadarshan K., Zarate-Perez, Francisco, Morris, Benjamin L., Nawaz, Zaid, Dennis, Michael J., Deng, Xiaoyan, Korwar, Sudha, Singh, Sahib J., Ellis, Keith C., Royer, William E., Bandyopadhyay, Dipankar, Escalante, Carlos, Grossman, Steven R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6560337/
https://ncbi.nlm.nih.gov/pubmed/31036695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.114363
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