CRISPR off-target analysis in genetically engineered rats and mice

Despite widespread use of CRISPR, comprehensive data on frequency and impact of Cas9-mediated off-targets in modified rodents is limited. Here, we present deep sequencing data from 81 mouse and rat genome editing projects and whole-genome sequencing data from 10 mouse embryos and their genetic paren...

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Udgivet i:Nat Methods
Main Authors: Anderson, Keith R., Haeussler, Maximilian, Watanabe, Colin, Janakiraman, Vasantharajan, Lund, Jessica, Modrusan, Zora, Stinson, Jeremy, Bei, Qixin, Buechler, Andrew, Yu, Charles, Thamminana, Sobha R., Tam, Lucinda, Sowick, Michael-Anne, Alcantar, Tuija, O’Neil, Natasha, Li, Jinjie, Ta, Linda, Lima, Lisa, Roose-Girma, Merone, Rairdan, Xin, Durinck, Steffen, Warming, Søren
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6558654/
https://ncbi.nlm.nih.gov/pubmed/29786090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-018-0011-5
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