Single-cell analysis reveals the KIT D816V mutation in haematopoietic stem and progenitor cells in systemic mastocytosis

BACKGROUND: Systemic mastocytosis (SM) is a haematological disease characterised by organ infiltration by neoplastic mast cells. Almost all SM patients have a mutation in the gene encoding the tyrosine kinase receptor KIT causing a D816V substitution and autoactivation of the receptor. Mast cells an...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Grootens, Jennine, Ungerstedt, Johanna S., Ekoff, Maria, Rönnberg, Elin, Klimkowska, Monika, Amini, Rose-Marie, Arock, Michel, Söderlund, Stina, Mattsson, Mattias, Nilsson, Gunnar, Dahlin, Joakim S.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6557764/
https://ncbi.nlm.nih.gov/pubmed/30975542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.03.089
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