KIT signaling is dispensable for human mast cell progenitor development

Human hematopoietic progenitors are generally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the formation of mast cells. Imatinib treatment, which inhibits KIT signaling, depletes mast cells in vivo. Furthermore, the absence of SCF or imatinib treatment preve...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Dahlin, Joakim S., Ekoff, Maria, Grootens, Jennine, Löf, Liza, Amini, Rose-Marie, Hagberg, Hans, Ungerstedt, Johanna S., Olsson-Strömberg, Ulla, Nilsson, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659818/
https://ncbi.nlm.nih.gov/pubmed/28790106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-773374
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