KIT signaling is dispensable for human mast cell progenitor development

Human hematopoietic progenitors are generally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the formation of mast cells. Imatinib treatment, which inhibits KIT signaling, depletes mast cells in vivo. Furthermore, the absence of SCF or imatinib treatment preve...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Dahlin, Joakim S., Ekoff, Maria, Grootens, Jennine, Löf, Liza, Amini, Rose-Marie, Hagberg, Hans, Ungerstedt, Johanna S., Olsson-Strömberg, Ulla, Nilsson, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2017
Matèries:
Plenary Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659818/
https://ncbi.nlm.nih.gov/pubmed/28790106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-773374
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