KIT signaling is dispensable for human mast cell progenitor development

Human hematopoietic progenitors are generally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the formation of mast cells. Imatinib treatment, which inhibits KIT signaling, depletes mast cells in vivo. Furthermore, the absence of SCF or imatinib treatment preve...

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Bibliographic Details
Published in:Blood
Main Authors: Dahlin, Joakim S., Ekoff, Maria, Grootens, Jennine, Löf, Liza, Amini, Rose-Marie, Hagberg, Hans, Ungerstedt, Johanna S., Olsson-Strömberg, Ulla, Nilsson, Gunnar
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5659818/
https://ncbi.nlm.nih.gov/pubmed/28790106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-773374
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