Histone deacetylase inhibitor SAHA mediates mast cell death and epigenetic silencing of constitutively active D816V KIT in systemic mastocytosis

Systemic mastocytosis (SM) is a clonal bone marrow disorder, where therapeutical options are limited. Over 90% of the patients carry the D816V point mutation in the KIT receptor that renders this receptor constitutively active. We assessed the sensitivity of primary mast cells (MC) and mast cell lin...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Lyberg, Katarina, Ali, Hani Abdulkadir, Grootens, Jennine, Kjellander, Matilda, Tirfing, Malin, Arock, Michel, Hägglund, Hans, Nilsson, Gunnar, Ungerstedt, Johanna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354760/
https://ncbi.nlm.nih.gov/pubmed/28038453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14181
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