Mastocytosis in mice expressing human Kit receptor with the activating Asp816Val mutation

Mastocytosis is a rare neoplastic disease characterized by a pathologic accumulation of tissue mast cells (MCs). Mastocytosis is often associated with a somatic point mutation in the Kit protooncogene leading to an Asp/Val substitution at position 816 in the kinase domain of this receptor. The contr...

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Autores principales: Zappulla, Jacques P., Dubreuil, Patrice, Desbois, Sabine, Létard, Sébastien, Hamouda, Nadine Ben, Daëron, Marc, Delsol, Georges, Arock, Michel, Liblau, Roland S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2005
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212965/
https://ncbi.nlm.nih.gov/pubmed/16352739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050807
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