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Sensitive and reliable detection of Kit point mutation Asp 816 to Val in pathological material
BACKGROUND: Human mastocytosis is a heterogenous disorder which is linked to a gain-of-function mutation in the kinase domain of the receptor tyrosine kinase Kit. This D816V mutation leads to constitutive activation and phosphorylation of Kit with proliferative disorders of mast cells in the periphe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211455/ https://ncbi.nlm.nih.gov/pubmed/17900365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-1596-2-37 |
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