Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic choleste...

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Publicado en:J Biol Chem
Autores principales: Pajed, Laura, Wagner, Carina, Taschler, Ulrike, Schreiber, Renate, Kolleritsch, Stephanie, Fawzy, Nermeen, Pototschnig, Isabella, Schoiswohl, Gabriele, Pusch, Lisa-Maria, Wieser, Beatrix I., Vesely, Paul, Hoefler, Gerald, Eichmann, Thomas O., Zimmermann, Robert, Lass, Achim
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556574/
https://ncbi.nlm.nih.gov/pubmed/31023823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007201
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