Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic choleste...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Pajed, Laura, Wagner, Carina, Taschler, Ulrike, Schreiber, Renate, Kolleritsch, Stephanie, Fawzy, Nermeen, Pototschnig, Isabella, Schoiswohl, Gabriele, Pusch, Lisa-Maria, Wieser, Beatrix I., Vesely, Paul, Hoefler, Gerald, Eichmann, Thomas O., Zimmermann, Robert, Lass, Achim
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Lipids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556574/
https://ncbi.nlm.nih.gov/pubmed/31023823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007201
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