Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic choleste...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Pajed, Laura, Wagner, Carina, Taschler, Ulrike, Schreiber, Renate, Kolleritsch, Stephanie, Fawzy, Nermeen, Pototschnig, Isabella, Schoiswohl, Gabriele, Pusch, Lisa-Maria, Wieser, Beatrix I., Vesely, Paul, Hoefler, Gerald, Eichmann, Thomas O., Zimmermann, Robert, Lass, Achim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2019
Konular:
Lipids
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556574/
https://ncbi.nlm.nih.gov/pubmed/31023823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007201
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