Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic choleste...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Pajed, Laura, Wagner, Carina, Taschler, Ulrike, Schreiber, Renate, Kolleritsch, Stephanie, Fawzy, Nermeen, Pototschnig, Isabella, Schoiswohl, Gabriele, Pusch, Lisa-Maria, Wieser, Beatrix I., Vesely, Paul, Hoefler, Gerald, Eichmann, Thomas O., Zimmermann, Robert, Lass, Achim
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2019
Sujets:
Lipids
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556574/
https://ncbi.nlm.nih.gov/pubmed/31023823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007201
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