Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover

Lysosomal acid lipase (LAL) is essential for the clearance of endocytosed cholesteryl ester and triglyceride-rich chylomicron remnants. Humans and mice with defective or absent LAL activity accumulate large amounts of cholesteryl esters and triglycerides in multiple tissues. Although chylomicrons al...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Grumet, Lukas, Eichmann, Thomas O., Taschler, Ulrike, Zierler, Kathrin A., Leopold, Christina, Moustafa, Tarek, Radovic, Branislav, Romauch, Matthias, Yan, Cong, Du, Hong, Haemmerle, Guenter, Zechner, Rudolf, Fickert, Peter, Kratky, Dagmar, Zimmermann, Robert, Lass, Achim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5016185/
https://ncbi.nlm.nih.gov/pubmed/27354281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.724054
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