Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation

Lysosomal acid lipase (LAL) hydrolyzes cholesteryl ester (CE) and retinyl ester (RE) and triglyceride (TG). Mice globally lacking LAL accumulate CE most prominently in the liver. The severity of the CE accumulation phenotype progresses with age and is accompanied by hepatomegaly and hepatic choleste...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Pajed, Laura, Wagner, Carina, Taschler, Ulrike, Schreiber, Renate, Kolleritsch, Stephanie, Fawzy, Nermeen, Pototschnig, Isabella, Schoiswohl, Gabriele, Pusch, Lisa-Maria, Wieser, Beatrix I., Vesely, Paul, Hoefler, Gerald, Eichmann, Thomas O., Zimmermann, Robert, Lass, Achim
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2019
Предметы:
Lipids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556574/
https://ncbi.nlm.nih.gov/pubmed/31023823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007201
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы