Bioinformatic and mutational studies of related toxin–antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues

Mycobacterium tuberculosis possesses an unusually large representation of type II toxin–antitoxin (TA) systems, whose functions and targets are mostly unknown. To better understand the basis of their unique expansion and to probe putative functional similarities among these systems, here we computat...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Tandon, Himani, Sharma, Arun, Wadhwa, Saruchi, Varadarajan, Raghavan, Singh, Ramandeep, Srinivasan, Narayanaswamy, Sandhya, Sankaran
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
Soggetti:
Computational Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556569/
https://ncbi.nlm.nih.gov/pubmed/31018964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006814
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