Bioinformatic and mutational studies of related toxin–antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues

Mycobacterium tuberculosis possesses an unusually large representation of type II toxin–antitoxin (TA) systems, whose functions and targets are mostly unknown. To better understand the basis of their unique expansion and to probe putative functional similarities among these systems, here we computat...

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Vydáno v:J Biol Chem
Hlavní autoři: Tandon, Himani, Sharma, Arun, Wadhwa, Saruchi, Varadarajan, Raghavan, Singh, Ramandeep, Srinivasan, Narayanaswamy, Sandhya, Sankaran
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Computational Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556569/
https://ncbi.nlm.nih.gov/pubmed/31018964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006814
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