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Bioinformatic and mutational studies of related toxin–antitoxin pairs in Mycobacterium tuberculosis predict and identify key functional residues

Mycobacterium tuberculosis possesses an unusually large representation of type II toxin–antitoxin (TA) systems, whose functions and targets are mostly unknown. To better understand the basis of their unique expansion and to probe putative functional similarities among these systems, here we computat...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Tandon, Himani, Sharma, Arun, Wadhwa, Saruchi, Varadarajan, Raghavan, Singh, Ramandeep, Srinivasan, Narayanaswamy, Sandhya, Sankaran
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556569/
https://ncbi.nlm.nih.gov/pubmed/31018964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006814
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