Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development

Lapatinib, an approved EGFR inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (NEU-1953), which was part of a series typically associated with poor aqueous so...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Bachovchin, Kelly A., Sharma, Amrita, Bag, Seema, Klug, Dana M., Schneider, Katherine M., Singh, Baljinder, Jalani, Hitesh B., Buskes, Melissa J., Mehta, Naimee, Tanghe, Scott, Momper, Jeremiah D., Sciotti, Richard J., Rodriguez, Ana, Mensa-Wilmot, Kojo, Pollastri, Michael P., Ferrins, Lori
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556231/
https://ncbi.nlm.nih.gov/pubmed/30565932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01365
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller