Structure–Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni

[Image: see text] We recently reported a series of compounds for a solubility-driven optimization campaign of antitrypanosomal compounds. Extending a parasite-hopping approach to the series, a subset of compounds from this library has been cross-screened for activity against the metazoan flatworm pa...

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Détails bibliographiques
Publié dans:ACS Med Chem Lett
Auteurs principaux: Buskes, Melissa J., Clements, Monica, Bachovchin, Kelly A., Jalani, Hitesh B., Leonard, Allison, Bag, Seema, Klug, Dana M., Singh, Baljinder, Campbell, Robert F., Sciotti, Richard J., El-Sakkary, Nelly, Caffrey, Conor R., Pollastri, Michael P., Ferrins, Lori
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2020
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073886/
https://ncbi.nlm.nih.gov/pubmed/32184954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00455
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