Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development

Lapatinib, an approved EGFR inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (NEU-1953), which was part of a series typically associated with poor aqueous so...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Med Chem
मुख्य लेखकों: Bachovchin, Kelly A., Sharma, Amrita, Bag, Seema, Klug, Dana M., Schneider, Katherine M., Singh, Baljinder, Jalani, Hitesh B., Buskes, Melissa J., Mehta, Naimee, Tanghe, Scott, Momper, Jeremiah D., Sciotti, Richard J., Rodriguez, Ana, Mensa-Wilmot, Kojo, Pollastri, Michael P., Ferrins, Lori
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556231/
https://ncbi.nlm.nih.gov/pubmed/30565932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01365
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