Improvement of Aqueous Solubility of Lapatinib-derived Analogs: Identification of a Quinolinimine as a Lead for Human African Trypanosomiasis Drug Development

Lapatinib, an approved EGFR inhibitor, was explored as a starting point for the synthesis of new hits against Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). Previous work culminated in 1 (NEU-1953), which was part of a series typically associated with poor aqueous so...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Bachovchin, Kelly A., Sharma, Amrita, Bag, Seema, Klug, Dana M., Schneider, Katherine M., Singh, Baljinder, Jalani, Hitesh B., Buskes, Melissa J., Mehta, Naimee, Tanghe, Scott, Momper, Jeremiah D., Sciotti, Richard J., Rodriguez, Ana, Mensa-Wilmot, Kojo, Pollastri, Michael P., Ferrins, Lori
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6556231/
https://ncbi.nlm.nih.gov/pubmed/30565932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b01365
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