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5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype

PURPOSE: Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine (5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5-hmC profiles would serve as novel prognostic markers in neuroblastoma, a clinically heterogeneous pediatric cancer. Becau...

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發表在:JCO Precis Oncol
Main Authors: Applebaum, Mark A., Barr, Erin K., Karpus, Jason, Nie, Ji, Zhang, Zhou, Armstrong, Amy E., Uppal, Sakshi, Sukhanova, Madina, Zhang, Wei, Chlenski, Alexandre, Salwen, Helen R., Wilkinson, Emma, Dobratic, Marija, Grossman, Robert, Godley, Lucy A., Stranger, Barbara E., He, Chuan, Cohn, Susan L.
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553657/
https://ncbi.nlm.nih.gov/pubmed/31179414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00402
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