5-Hydroxymethylcytosine Profiles Are Prognostic of Outcome in Neuroblastoma and Reveal Transcriptional Networks That Correlate With Tumor Phenotype

PURPOSE: Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine (5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5-hmC profiles would serve as novel prognostic markers in neuroblastoma, a clinically heterogeneous pediatric cancer. Becau...

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Detalhes bibliográficos
Publicado no:JCO Precis Oncol
Main Authors: Applebaum, Mark A., Barr, Erin K., Karpus, Jason, Nie, Ji, Zhang, Zhou, Armstrong, Amy E., Uppal, Sakshi, Sukhanova, Madina, Zhang, Wei, Chlenski, Alexandre, Salwen, Helen R., Wilkinson, Emma, Dobratic, Marija, Grossman, Robert, Godley, Lucy A., Stranger, Barbara E., He, Chuan, Cohn, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2019
Assuntos:
Original Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553657/
https://ncbi.nlm.nih.gov/pubmed/31179414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.18.00402
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