5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease burden in children with neuroblastoma

PURPOSE: 5-hydroxymethylcytosine (5-hmC) is an epigenetic marker of open chromatin and active gene expression. We profiled 5-hmC with Nano-hmC-Seal technology using 10ng of plasma derived cell-free DNA (cfDNA) in blood samples from patients with neuroblastoma to determine its utility as a biomarker....

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Publicado no:Clin Cancer Res
Main Authors: Applebaum, Mark A., Barr, Erin K., Karpus, Jason, West-Szymanski, Diana C., Oliva, Meritxell, Sokol, Elizabeth A., Zhang, Sheng, Zhang, Zhou, Zhang, Wei, Chlenski, Alexandre, Salwen, Helen R., Wilkinson, Emma, Dobratic, Marija, Grossman, Robert L., Godley, Lucy A., Stranger, Barbara E., He, Chuan, Cohn, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073281/
https://ncbi.nlm.nih.gov/pubmed/31852832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-2829
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