Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

SCOPE: DNA repair inhibitors have broad clinical applications in tumor types with DNA repair defects, including colorectal cancer (CRC). Structural analogs of the anticancer agent sulforaphane (SFN) were investigated as modifiers of histone deacetylase (HDAC) and histone acetyltransferase (HAT) acti...

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Detalhes bibliográficos
Publicado no:Mol Nutr Food Res
Main Authors: Okonkwo, Adaobi, Mitra, Joy, Johnson, Gavin S., Li, Li, Dashwood, Wan Mohaiza, Hegde, Muralidhar L., Yue, Chen, Dashwood, Roderick H., Rajendran, Praveen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553464/
https://ncbi.nlm.nih.gov/pubmed/29924908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201800228
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