Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly

BACKGROUND: Histone deacetylase (HDAC) inhibitors are currently undergoing clinical evaluation as anti-cancer agents. Dietary constituents share certain properties of HDAC inhibitor drugs, including the ability to induce global histone acetylation, turn-on epigenetically-silenced genes, and trigger...

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Detalhes bibliográficos
Main Authors: Rajendran, Praveen, Delage, Barbara, Dashwood, W Mohaiza, Yu, Tian-Wei, Wuth, Bradyn, Williams, David E, Ho, Emily, Dashwood, Roderick H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127849/
https://ncbi.nlm.nih.gov/pubmed/21624135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-68
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