Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

SCOPE: DNA repair inhibitors have broad clinical applications in tumor types with DNA repair defects, including colorectal cancer (CRC). Structural analogs of the anticancer agent sulforaphane (SFN) were investigated as modifiers of histone deacetylase (HDAC) and histone acetyltransferase (HAT) acti...

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Bibliografske podrobnosti
izdano v:Mol Nutr Food Res
Main Authors: Okonkwo, Adaobi, Mitra, Joy, Johnson, Gavin S., Li, Li, Dashwood, Wan Mohaiza, Hegde, Muralidhar L., Yue, Chen, Dashwood, Roderick H., Rajendran, Praveen
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6553464/
https://ncbi.nlm.nih.gov/pubmed/29924908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mnfr.201800228
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