Telomerase reverse transcriptase ameliorates lung fibrosis by protecting alveolar epithelial cells against senescence

Mutations in the genes encoding telomerase reverse transcriptase (TERT) and telomerase's RNA components as well as shortened telomeres are risk factors for idiopathic pulmonary fibrosis, where repetitive injury to the alveolar epithelium is considered a key factor in pathogenesis. Given the imp...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Liu, Tianju, Gonzalez De Los Santos, Francina, Zhao, Yuyue, Wu, Zhe, Rinke, Andrew E., Kim, Kevin K., Phan, Sem H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6552422/
https://ncbi.nlm.nih.gov/pubmed/31000627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006615
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