Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial

IMPORTANCE: Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. OBJECTIVE: To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with an oral antidepressant plus plac...

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Bibliographic Details
Published in:JAMA Psychiatry
Main Authors: Daly, Ella J., Trivedi, Madhukar H., Janik, Adam, Li, Honglan, Zhang, Yun, Li, Xiang, Lane, Rosanne, Lim, Pilar, Duca, Anna R., Hough, David, Thase, Michael E., Zajecka, John, Winokur, Andrew, Divacka, Ilona, Fagiolini, Andrea, Cubała, Wiesław J., Bitter, István, Blier, Pierre, Shelton, Richard C., Molero, Patricio, Manji, Husseini, Drevets, Wayne C., Singh, Jaskaran B.
Format: Artigo
Language:Inglês
Published: American Medical Association 2019
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551577/
https://ncbi.nlm.nih.gov/pubmed/31166571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2019.1189
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