Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

BACKGROUND: About one-third of patients with depression fail to achieve remission despite treatment with multiple antidepressants and are considered to have treatment-resistant depression. METHODS: This Phase 3, double-blind, multicenter study enrolled adults with moderate-to-severe depression and n...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Fedgchin, Maggie, Trivedi, Madhukar, Daly, Ella J, Melkote, Rama, Lane, Rosanne, Lim, Pilar, Vitagliano, Dawn, Blier, Pierre, Fava, Maurizio, Liebowitz, Michael, Ravindran, Arun, Gaillard, Raphael, Ameele, Hans Van Den, Preskorn, Sheldon, Manji, Husseini, Hough, David, Drevets, Wayne C, Singh, Jaskaran B
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Regular Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6822141/
https://ncbi.nlm.nih.gov/pubmed/31290965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyz039
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