Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial

IMPORTANCE: Controlled studies have shown short-term efficacy of esketamine for treatment-resistant depression (TRD), but long-term effects remain to be established. OBJECTIVE: To assess the efficacy of esketamine nasal spray plus an oral antidepressant compared with an oral antidepressant plus plac...

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Detalhes bibliográficos
Publicado no:JAMA Psychiatry
Main Authors: Daly, Ella J., Trivedi, Madhukar H., Janik, Adam, Li, Honglan, Zhang, Yun, Li, Xiang, Lane, Rosanne, Lim, Pilar, Duca, Anna R., Hough, David, Thase, Michael E., Zajecka, John, Winokur, Andrew, Divacka, Ilona, Fagiolini, Andrea, Cubała, Wiesław J., Bitter, István, Blier, Pierre, Shelton, Richard C., Molero, Patricio, Manji, Husseini, Drevets, Wayne C., Singh, Jaskaran B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2019
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551577/
https://ncbi.nlm.nih.gov/pubmed/31166571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2019.1189
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