Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial

IMPORTANCE: Approximately one-third of patients with major depressive disorder (MDD) do not respond to available antidepressants. OBJECTIVE: To assess the efficacy, safety, and dose-response of intranasal esketamine hydrochloride in patients with treatment-resistant depression (TRD). DESIGN, SETTING...

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Bibliographic Details
Published in:JAMA Psychiatry
Main Authors: Daly, Ella J., Singh, Jaskaran B., Fedgchin, Maggie, Cooper, Kimberly, Lim, Pilar, Shelton, Richard C., Thase, Michael E., Winokur, Andrew, Van Nueten, Luc, Manji, Husseini, Drevets, Wayne C.
Format: Artigo
Language:Inglês
Published: American Medical Association 2017
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5838571/
https://ncbi.nlm.nih.gov/pubmed/29282469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamapsychiatry.2017.3739
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