Effects of Mu-Opiate Receptor Gene Polymorphism rs1799971 (A118G) on the Antidepressant and Dissociation Responses in Esketamine Nasal Spray Clinical Trials

BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, noncompetitive, N-methyl-D-aspartate receptor antagonists. However, at substantially higher doses, ketamine has shown mu-opioid receptor (MOR–gene symbol: OPRM1) agonist ef...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Saad, Ziad, Hibar, Derrek, Fedgchin, Maggie, Popova, Vanina, Furey, Maura L, Singh, Jaskaran B, Kolb, Hartmuth, Drevets, Wayne C, Chen, Guang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Regular Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710914/
https://ncbi.nlm.nih.gov/pubmed/32367114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyaa030
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