Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Base editing requires that the target sequence satisfy the PAM requirement of the Cas9 domain and that the target nucleotide is located within the editing window of the base editor. To increase the targeting scope of base editors, we engineered six optimized adenine base editors (ABEmax variants) th...

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Bibliografiske detaljer
Udgivet i:Nat Biotechnol
Main Authors: Huang, Tony P., Zhao, Kevin T., Miller, Shannon M., Gaudelli, Nicole M., Oakes, Benjamin L., Fellmann, Christof, Savage, David F., Liu, David R.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551276/
https://ncbi.nlm.nih.gov/pubmed/31110355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0134-y
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