טוען...
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
Base editing requires that the target sequence satisfy the PAM requirement of the Cas9 domain and that the target nucleotide is located within the editing window of the base editor. To increase the targeting scope of base editors, we engineered six optimized adenine base editors (ABEmax variants) th...
שמור ב:
| הוצא לאור ב: | Nat Biotechnol |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2019
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6551276/ https://ncbi.nlm.nih.gov/pubmed/31110355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0134-y |
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