Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Base editing requires that the target sequence satisfy the PAM requirement of the Cas9 domain and that the target nucleotide is located within the editing window of the base editor. To increase the targeting scope of base editors, we engineered six optimized adenine base editors (ABEmax variants) th...

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Detalhes bibliográficos
Publicado no:Nat Biotechnol
Main Authors: Huang, Tony P., Zhao, Kevin T., Miller, Shannon M., Gaudelli, Nicole M., Oakes, Benjamin L., Fellmann, Christof, Savage, David F., Liu, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551276/
https://ncbi.nlm.nih.gov/pubmed/31110355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41587-019-0134-y
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