ATR inhibition potentiates the radiation induced inflammatory tumor microenvironment

PURPOSE: ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitise to chemotherapy and radiotherapy preclinically. Limited data have been published about the effect of these drugs on the tumor microenvironment. EXPERIMENTAL DESIGN: We used an immunocompetent mouse mod...

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Publicado no:Clin Cancer Res
Main Authors: Dillon, Magnus T., Bergerhoff, Katharina F., Pedersen, Malin, Whittock, Harriet, Crespo-Rodriguez, Eva, Patin E, Emmanuel C., Pearson, Alex, Smith, Henry G., Paget, James T. E., Patel, Radhika R., Foo, Shane, Bozhanova, Galabina, Ragulan, Chanthirika, Fontana, Elisa, Desai, Krisha, Wilkins, Anna C., Sadanandam, Anguraj, Melcher, Alan, McLaughlin, Martin, Harrington, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551222/
https://ncbi.nlm.nih.gov/pubmed/30770349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1821
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