Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei

AZD6738 is an orally active ATR inhibitor (ATRi) currently in phase I clinical trials. We found in vitro growth inhibitory activity of this ATRi in a panel of human cancer cell lines. We demonstrated radiosensitization by AZD6738 to single radiation fractions in multiple cancer cell lines independen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Dillon, Magnus T., Barker, Holly E., Pedersen, Malin, Hafsi, Hind, Bhide, Shreerang A., Newbold, Kate L., Nutting, Christopher M., McLaughlin, Martin, Harrington, Kevin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302142/
https://ncbi.nlm.nih.gov/pubmed/28062704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0239
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge