Combined ATR and DNA-PK Inhibition Radiosensitizes Tumor Cells Independently of Their p53 Status

Head and neck squamous cell carcinoma (HNSCC) is a significant cause of cancer deaths. Cisplatin-based chemoradiotherapy is a standard of care for locally advanced disease. ATR and DNA-PK inhibition (DNA-PKi) are actively being investigated in clinical trials with preclinical data supporting clinica...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Hafsi, Hind, Dillon, Magnus T., Barker, Holly E., Kyula, Joan N., Schick, Ulrike, Paget, James T., Smith, Henry G., Pedersen, Malin, McLaughlin, Martin, Harrington, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053502/
https://ncbi.nlm.nih.gov/pubmed/30057890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00245
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