ATR inhibition potentiates the radiation induced inflammatory tumor microenvironment

PURPOSE: ATR inhibitors (ATRi) are in early phase clinical trials and have been shown to sensitise to chemotherapy and radiotherapy preclinically. Limited data have been published about the effect of these drugs on the tumor microenvironment. EXPERIMENTAL DESIGN: We used an immunocompetent mouse mod...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Dillon, Magnus T., Bergerhoff, Katharina F., Pedersen, Malin, Whittock, Harriet, Crespo-Rodriguez, Eva, Patin E, Emmanuel C., Pearson, Alex, Smith, Henry G., Paget, James T. E., Patel, Radhika R., Foo, Shane, Bozhanova, Galabina, Ragulan, Chanthirika, Fontana, Elisa, Desai, Krisha, Wilkins, Anna C., Sadanandam, Anguraj, Melcher, Alan, McLaughlin, Martin, Harrington, Kevin J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6551222/
https://ncbi.nlm.nih.gov/pubmed/30770349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1821
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