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Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei

AZD6738 is an orally active ATR inhibitor (ATRi) currently in phase I clinical trials. We found in vitro growth inhibitory activity of this ATRi in a panel of human cancer cell lines. We demonstrated radiosensitization by AZD6738 to single radiation fractions in multiple cancer cell lines independen...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Dillon, Magnus T., Barker, Holly E., Pedersen, Malin, Hafsi, Hind, Bhide, Shreerang A., Newbold, Kate L., Nutting, Christopher M., McLaughlin, Martin, Harrington, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302142/
https://ncbi.nlm.nih.gov/pubmed/28062704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0239
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