Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance

Prostate cancers harboring DNA repair gene alterations are particularly sensitive to PARP inhibitor treatment. We report a case of an advanced prostate cancer patient profiled within the NCT-MASTER (Molecularly Aided Stratification for Tumor Eradication Research) precision oncology program using nex...

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Pubblicato in:Cold Spring Harb Mol Case Stud
Autori principali: Horak, Peter, Weischenfeldt, Joachim, von Amsberg, Gunhild, Beyer, Burkhard, Schütte, Andreas, Uhrig, Sebastian, Gieldon, Laura, Klink, Barbara, Feuerbach, Lars, Hübschmann, Daniel, Kreutzfeldt, Simon, Heining, Christoph, Maier, Sebastian, Hutter, Barbara, Penzel, Roland, Schlesner, Matthias, Eils, Roland, Sauter, Guido, Stenzinger, Albrecht, Brors, Benedikt, Schröck, Evelin, Glimm, Hanno, Fröhling, Stefan, Schlomm, Thorsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2019
Soggetti:
Research Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549578/
https://ncbi.nlm.nih.gov/pubmed/30833416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a003657
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