Response to olaparib in a PALB2 germline mutated prostate cancer and genetic events associated with resistance

Prostate cancers harboring DNA repair gene alterations are particularly sensitive to PARP inhibitor treatment. We report a case of an advanced prostate cancer patient profiled within the NCT-MASTER (Molecularly Aided Stratification for Tumor Eradication Research) precision oncology program using nex...

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Bibliografiska uppgifter
I publikationen:Cold Spring Harb Mol Case Stud
Huvudupphovsmän: Horak, Peter, Weischenfeldt, Joachim, von Amsberg, Gunhild, Beyer, Burkhard, Schütte, Andreas, Uhrig, Sebastian, Gieldon, Laura, Klink, Barbara, Feuerbach, Lars, Hübschmann, Daniel, Kreutzfeldt, Simon, Heining, Christoph, Maier, Sebastian, Hutter, Barbara, Penzel, Roland, Schlesner, Matthias, Eils, Roland, Sauter, Guido, Stenzinger, Albrecht, Brors, Benedikt, Schröck, Evelin, Glimm, Hanno, Fröhling, Stefan, Schlomm, Thorsten
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2019
Ämnen:
Research Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6549578/
https://ncbi.nlm.nih.gov/pubmed/30833416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a003657
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