Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage

Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation regulatory network that controls p53 expression post DNA damag...

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Udgivet i:iScience
Main Authors: Guha, Abhishek, Ahuja, Deepika, Das Mandal, Sukhen, Parasar, Bibudha, Deyasi, Krishanu, Roy, Debadrita, Sharma, Vasundhara, Willard, Belinda, Ghosh, Anandamohan, Ray, Partho Sarothi
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548907/
https://ncbi.nlm.nih.gov/pubmed/31103853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.05.002
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