Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage

Expression of tumor suppressor p53 is regulated at multiple levels, disruption of which often leads to cancer. We have adopted an approach combining computational systems modeling with experimental validation to elucidate the translation regulatory network that controls p53 expression post DNA damag...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:iScience
Κύριοι συγγραφείς: Guha, Abhishek, Ahuja, Deepika, Das Mandal, Sukhen, Parasar, Bibudha, Deyasi, Krishanu, Roy, Debadrita, Sharma, Vasundhara, Willard, Belinda, Ghosh, Anandamohan, Ray, Partho Sarothi
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Elsevier 2019
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548907/
https://ncbi.nlm.nih.gov/pubmed/31103853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.05.002
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