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Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress

Tumor suppressor protein p53 plays a crucial role in maintaining genomic integrity in response to DNA damage. Regulation of translation of p53 mRNA is a major mode of regulation of p53 expression under genotoxic stress. The AU/U-rich element-binding protein HuR has been shown to bind to p53 mRNA 3′U...

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Detalhes bibliográficos
Publicado no:RNA Biol
Main Authors: Ahuja, Deepika, Goyal, Ashish, Ray, Partho Sarothi
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100343/
https://ncbi.nlm.nih.gov/pubmed/27592685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2016.1229734
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