Tissue-specific oncogenic activity of K-Ras(A146T)

KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant K-Ras proteins. We used a cross-disciplinary approach to compare K-Ras(G...

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Bibliografske podrobnosti
izdano v:Cancer Discov
Main Authors: Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian A., Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A., Westover, Kenneth D., Haigis, Kevin M.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548671/
https://ncbi.nlm.nih.gov/pubmed/30952657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1220
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