Tissue-specific oncogenic activity of K-Ras(A146T)

KRAS is the most frequently mutated oncogene. The incidence of specific KRAS alleles varies between cancers from different sites, but it is unclear whether allelic selection results from biological selection for specific mutant K-Ras proteins. We used a cross-disciplinary approach to compare K-Ras(G...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian A., Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A., Westover, Kenneth D., Haigis, Kevin M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548671/
https://ncbi.nlm.nih.gov/pubmed/30952657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-1220
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