Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck

PURPOSE: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora...

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Pubblicato in:Clin Cancer Res
Autori principali: Lee, Jong Woo, Parameswaran, Janaki, Sandoval-Schaefer, Teresa, Eoh, Kyung Jin, Yang, Dong-hua, Zhu, Fang, Mehra, Ranee, Sharma, Roshan, Gaffney, Stephen G., Perry, Elizabeth B., Townsend, Jeffrey P., Serebriiskii, Ilya G., Golemis, Erica A., Issaeva, Natalia, Yarbrough, Wendell G., Koo, Ja Seok, Burtness, Barbara
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548643/
https://ncbi.nlm.nih.gov/pubmed/30755439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0440
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