Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck

PURPOSE: Human papillomavirus (HPV)-negative head and neck squamous cell carcinomas (HNSCC) commonly bear disruptive mutations in TP53, resulting in treatment resistance. In these patients, direct targeting of p53 has not been successful, but synthetic lethal approaches have promise. Although Aurora...

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Detaylı Bibliyografya
Yayımlandı:Clin Cancer Res
Asıl Yazarlar: Lee, Jong Woo, Parameswaran, Janaki, Sandoval-Schaefer, Teresa, Eoh, Kyung Jin, Yang, Dong-hua, Zhu, Fang, Mehra, Ranee, Sharma, Roshan, Gaffney, Stephen G., Perry, Elizabeth B., Townsend, Jeffrey P., Serebriiskii, Ilya G., Golemis, Erica A., Issaeva, Natalia, Yarbrough, Wendell G., Koo, Ja Seok, Burtness, Barbara
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548643/
https://ncbi.nlm.nih.gov/pubmed/30755439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-0440
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